AN UNBIASED VIEW OF TETRAHYDROBIOPTERINPKU

BH4 metabolism can instead be depicted being a cytoprotective pathway that is finely controlled via the concerted motion of de novo, salvage, and recycling pathways to manage intracellular concentrations of BH4 and BH4-relevant metabolites. If this finely tuned balance in BH4 focus is perturbed, a number of biological programs are compromised, lead